1. The cardiovascular benefits of testosterone therapy are numerous. These study authors showed that restoration of natural steroid hormones like testosterone provided a favorable benefit on cholesterol profiles. Cardiologists should consider hormone replacement to provide additional cardiovascular benefits.
2. There is an inverse relationship between testosterone levels and procoagulable factors such as plasminogen activator inhibitor and fibrinogen. Testosterone replacement may help with decreasing coagulation factors.
3. There is mounting evidence to suggest that low testosterone levels are associated with increased risk of cerebrovascular disease in men.
4. Optimized testosterone levels have been shown to decrease endothelial resistance and act as a potent vasodilator.
5. Higher total testosterone and sex-hormone binding globulin levels are inversely related to carotid atherosclerosis in postmenopausal women. This lends evidence to the suggestion that higher testosterone levels may play a major role in reducing atherosclerotic risk in postmenopausal women not using hormone replacement therapy.
6. This study demonstrated that men with higher free testosterone levels had better left ventricular ejection fractions (better cardiac output).
7. Testosterone is a potent vasodilator and at physiologic concentrations can induce coronary artery dilation and increases coronary blood flow in men with established coronary artery disease.
8. Testosterone levels at optimized physiologic levels improve insulin resistance by improving insulin receptor function. This means that testosterone can lower blood glucose levels and improve blood glucose profiles.
9. Men with low free and total testosterone were shown to have higher incidence of hyperinsuinemia.
10. Optimized physiological levels of testosterone improved erectile dysfunction in men.
11. Low physiological levels of testosterone are an independent risk factor for developing Alzheimer’s Disease.
12. Optimized levels of testosterone prevent osteoporosis in men by increasing bone mineral density (BMD). In women, testosterone with estradiol in combination showed dramatic improvements in bone mass after one year of therapy.
13. This article in the prestigious New England Journal of Medicine showed that optimized testosterone levels (via transdermal patch) improved sexual function in women after oophorectomy and hysterectomy.
14. Optimized testosterone levels in males increases muscle mass. Physiologic testosterone levels also maintain strength and bone mass.
15. Low total testosterone levels are associated with increased BMI and diabetes.
16. In elderly men, testosterone supplementation increases human growth hormone (HGH) production. HGH is a super-hormone that plays a vital role in regulating body composition, production of body fluids, muscle and bone growth and fat metabolism.
17. Wound Healing. Optimized testosterone levels can improve wound healing especially in the elderly.
18. Improved Cognition. Optimized levels of testosterone until death can improve cognition, maintain a better affect, and allow for better thinking and processing skills.
19. Testosterone has shown a significant neuroprotective role in hypogonadal men with improvements in Alzheimer’s disease, MS, Huntington’s disease and Parkinson’s disease.
20. Vaginal or vulvovaginal atrophy is a widespread but poorly recognized condition of peri- and post-menopausal women. Vaginal or vulvovaginal atrophy is a widespread but poorly recognized condition of peri- and post-menopausal women. Testosterone replacement therapy is an effective treatement and preventative therapy for vulvovaginal atrophy.
